CAPG Gene Summary [Human]
This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | CAPG |
| Official Name | capping actin protein, gelsolin like [Source:HGNC Symbol;Acc:HGNC:1474] |
| Ensembl ID | ENSG00000042493 |
| Bio databases IDs | |
| Aliases | capping actin protein, gelsolin like, macrophage capping protein |
| Synonyms | AFCP, capping actin protein, gelsolin like, gCap39, HEL-S-66, MACHROPHAGE CAPPING, mbh1, MCP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CAPG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- binding protein
- Gelsolin repeat
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- idiopathic scoliosis
- atopic dermatitis
- HER2 negative hormone receptor negative breast cancer
- rheumatoid arthritis
- peripheral arterial disease
- tauopathy
- autoimmune pancreatitis
- metastatic colorectal cancer
- insulin-dependent diabetes mellitus
regulates
- ACTIN
- PI3K (complex)
role in cell
- apoptosis
- proliferation
- assembly
- phagocytosis
- function
- phagocytosis by
- response by
- ruffling
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- centriole
- Flemming body
- chromosome
- nucleoplasm
- nucleoli
- mitotic spindle
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CAPG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- barbed-end actin filament capping
- actin filament severing
- central nervous system development
- macromolecular complex assembly
- actin polymerization or depolymerization
- extracellular matrix disassembly
- cell projection assembly
- positive regulation of podosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleolus
- nucleoplasm
- nucleus
- extracellular vesicular exosome
- mitotic spindle
- cytoplasm
- melanosome
- centriole
- actin cytoskeleton
- ruffle
- F-actin capping protein complex
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein domain specific binding
- protein binding
- cadherin binding