TREX2 Gene Summary [Human]
This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | TREX2 |
| Official Name | three prime repair exonuclease 2 [Source:HGNC Symbol;Acc:HGNC:12270] |
| Ensembl ID | ENSG00000183479 |
| Bio databases IDs | |
| Aliases | three prime repair exonuclease 2 |
| Synonyms | RGD1562245, three prime repair exonuclease 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TREX2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- exonuclease
- EXOIII
- protein homodimerization
- enzyme
- protein binding
- magnesium ion binding
- 3'-5' exodeoxyribonuclease
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TREX2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA catabolic process
- DNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- DNA binding
- protein binding
- protein homodimerization activity
- 3'-5'-exodeoxyribonuclease activity
- double-stranded DNA specific 3'-5' exodeoxyribonuclease activity
- binding, bridging