PPP2CA Gene Summary [Human]
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPP2CA |
| Official Name | protein phosphatase 2 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9299] |
| Ensembl ID | ENSG00000113575 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2 catalytic subunit alpha, protein phosphatase 2A catalytic subunit, alpha isoform |
| Synonyms | C α, HJS3, LOC103694903, NEDLBA, PP2A, Pp2a1, PP2Ac, PP2AC alpha, PP2AC α, PP2CA, PP2Calpha, protein phosphatase 2 catalytic subunit alpha, protein phosphatase 2 catalytic subunit α, protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform, protein phosphatase 2 (formerly 2A), catalytic subunit, α isoform, R75353, RP-C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP2CA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein-tyrosine-phoshatase
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- protein phosphatase binding
- G-protein-coupled receptor binding
- enzyme binding
- antigen binding
- protein domain specific binding
- metallophosphatase superfamily, metallophosphatase domain
- protein binding
- receptor binding
- identical protein binding
- Calcineurin-like phosphoesterase
- CTD phosphatase
- binding protein
- tau protein binding
- protein phosphatase
- phosphatase
- ion channel binding
- Protein phosphatase 2A homologues, catalytic domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the PPP2CA gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Protein Kinase A Signaling
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of Tissue Factor in Cancer
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- systemic lupus erythematosus
- autoimmune glomerulonephritis
- tumorigenesis
- hereditary disorder
- psoriasis
- neurodevelopmental disorder and language delay with or without structural brain abnormalities
- Waldenström macroglobulinemia
- prostate cancer
- chronic lymphocytic leukemia
role in cell
- production in
- expression in
- phosphorylation in
- apoptosis
- survival
- proliferation
- elongation
- elongation in
- quantity
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- cell pole
- Nucleus
- Plasma Membrane
- centrosome
- cytosol
- spindle pole
- neurites
- synapse
- membrane rafts
- centromeres
- chromatin
- axons
- axon terminals
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP2CA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of hippo signaling cascade
- peptidyl-threonine dephosphorylation
- protein dephosphorylation
- mesoderm development
- positive regulation of NLRP3 inflammasome complex assembly
- regulation of growth
- mitotic cell cycle
- T cell homeostasis
- peptidyl-serine dephosphorylation
- meiotic cell cycle
- negative regulation of epithelial to mesenchymal transition
- regulation of cell differentiation
- regulation of protein phosphorylation
- regulation of G1/S transition of mitotic cell cycle
- response to lead ion
- positive regulation of protein serine/threonine kinase activity
- intracellular signal transduction
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- protein serine/threonine phosphatase complex
- spindle pole
- synapse
- protein phosphatase type 2A complex
- chromosome, centromeric region
- plasma membrane
- nucleus
- extracellular vesicular exosome
- membrane raft
- membrane
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- phosphoprotein phosphatase activity
- protein binding
- metal ion binding
- protein tyrosine phosphatase activity
- protein heterodimerization activity
- tau protein binding
- GABA receptor binding
- myosin phosphatase activity