THRAP3 Gene Summary [Human]
Enables phosphoprotein binding activity; thyroid hormone receptor binding activity; and transcription coactivator activity. Involved in nuclear-transcribed mRNA catabolic process; positive regulation of circadian rhythm; and regulation of RNA metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of mediator complex. Colocalizes with exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | THRAP3 |
| Official Name | thyroid hormone receptor associated protein 3 [Source:HGNC Symbol;Acc:HGNC:22964] |
| Ensembl ID | ENSG00000054118 |
| Bio databases IDs | |
| Aliases | thyroid hormone receptor associated protein 3, TR-associated protein, 150-kDa, BCLAF1 and THRAP3 family member 2 |
| Synonyms | 9330151F09Rik, B230333E16Rik, BCLAF2, Similar to thyroid hormone receptorassociated protein, 150 kDa, Thyroid Hormone Receptor Associated Protein, 150 kDa, Thyroid Hormone Receptor-Associated Protein 3, TRAP150 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THRAP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- double-stranded DNA binding
- nucleic acid binding
- THRAP3/BCLAF1 family
- transcription cofactor
- phosphoprotein binding
- protein binding
- sequence-specific DNA binding
- thyroid hormone receptor binding
Pathways
Biological processes and signaling networks where the THRAP3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic fatty liver disease
- non-insulin-dependent diabetes mellitus
- preeclampsia
- gastroesophageal reflux
- insulin resistance
- hyperglycemia
role in cell
- differentiation
- expression in
- proliferation
- degradation in
- binding in
- osteogenesis
- alternative splicing by
- acidification in
- G2/M phase
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THRAP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- positive regulation of transcription, DNA-dependent
- regulation of alternative nuclear mRNA splicing, via spliceosome
- positive regulation of nuclear mRNA splicing, via spliceosome
- mRNA stabilization
- nuclear-transcribed mRNA catabolic process
- mRNA processing
- positive regulation of transcription from RNA polymerase II promoter
- circadian rhythm
- positive regulation of circadian rhythm
Cellular Component
Where in the cell the gene product is active
- nucleus
- exon-exon junction complex
- extracellular vesicular exosome
- nuclear speck
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ATP binding
- RNA binding
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- ligand-dependent nuclear receptor transcription coactivator activity
- vitamin D receptor binding
- phosphoprotein binding
- thyroid hormone receptor binding