ZFP36L2 Gene Summary [Human]
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ZFP36L2 |
| Official Name | ZFP36 ring finger protein like 2 [Source:HGNC Symbol;Acc:HGNC:1108] |
| Ensembl ID | ENSG00000152518 |
| Bio databases IDs | |
| Aliases | ZFP36 ring finger protein like 2 |
| Synonyms | BRF2, Butyrate response factor 2, ERF-2, LOC100363714, LOC100911319, OOMD13, OZEMA13, RNF162C, TIS11D, ZFP36 ring finger protein like 2, zinc finger protein 36, C3H type-like 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFP36L2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger
- transcription regulator
- mRNA 3' UTR binding
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- zinc finger domain
- Tis11B like protein, N terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- epithelial cancer
- epithelial neoplasia
- cancer
- open-angle glaucoma
- COVID-19
- breast cancer
- metastatic colorectal cancer
- cholangiocarcinoma cancer
- liver cancer
role in cell
- expression in
- binding in
- apoptosis
- differentiation
- degradation in
- number
- function
- integrity
- hematopoiesis
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFP36L2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-UTR-mediated mRNA destabilization
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- T cell differentiation in thymus
- hemopoiesis
- response to wounding
- negative regulation of fat cell differentiation
- regulation of B cell differentiation
- cellular response to fibroblast growth factor stimulus
- regulation of mRNA stability
- mRNA catabolic process
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- definitive hemopoiesis
- ERK1 and ERK2 cascade
- cellular response to transforming growth factor beta stimulus
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
- somatic stem cell division
- cellular response to glucocorticoid stimulus
- cellular response to epidermal growth factor stimulus
- negative regulation of stem cell differentiation
- somatic stem cell maintenance
- cellular response to tumor necrosis factor
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA 3'-UTR AU-rich region binding
- metal ion binding