KIF1B Gene Summary [Human]
Predicted to enable microtubule binding activity and plus-end-directed microtubule motor activity. Predicted to be involved in chemical synaptic transmission; dense core granule cytoskeletal transport; and vesicle-mediated transport. Predicted to act upstream of or within mitochondrion transport along microtubule. Predicted to be located in cytoplasmic vesicle membrane and neuron projection. Predicted to be part of kinesin complex. Predicted to be active in several cellular components, including axon; dendrite; and microtubule. Implicated in Charcot-Marie-Tooth disease type 2A1; carcinoma (multiple); multiple sclerosis; neuroblastoma; and pheochromocytoma. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KIF1B |
| Official Name | kinesin family member 1B [Source:HGNC Symbol;Acc:HGNC:16636] |
| Ensembl ID | ENSG00000054523 |
| Bio databases IDs | |
| Aliases | kinesin family member 1B, Charcot-Marie-Tooth neuropathy type II |
| Synonyms | A530096N05Rik, CMT2, CMT2A, CMT2A1, D4Mil1e, HMSNII, KIF1Bp130, KIF1Bp204, Kinesin-1B, kinesin family member 1B, Kip1p, KLP, NBLST1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin protein 1B
- Myosin and Kinesin motor domain
- Forkhead associated domain
- Pleckstrin homology-like domain
- protein binding
- ATPase
- microtubule motor protein
- kinesin binding
- Kinesin-associated
- forkhead associated (FHA) domain superfamily
- Kinesin motor, catalytic domain
- microtubule binding
- Kinesin protein
- kinase binding
- FHA domain
- Kinesin motor domain
- PH domain
- tail domain
- plus-end-directed kinesin ATPase
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- cancer
- hepatocellular carcinoma
- epithelial cancer
- multiple sclerosis
- Parkinson disease
- susceptibility to neuroblastoma
- hemangioma
- angiomatosis
- Charcot-Marie-Tooth disease type 2A1
role in cell
- apoptosis
- expression in
- differentiation
- transport in
- accumulation in
- survival
- outgrowth
- quantity
- number
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- presynaptic regions
- postsynaptic region
- Mitochondria
- synaptic vesicles
- neurites
- cytoplasmic vesicles
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron-neuron synaptic transmission
- vesicle-mediated transport
- cytoskeleton-dependent intracellular transport
- neuromuscular synaptic transmission
- apoptotic process
- microtubule-based movement
- anterograde synaptic vesicle transport
Cellular Component
Where in the cell the gene product is active
- dendrite
- mitochondrion
- cytoplasmic vesicle
- kinesin complex
- synaptic vesicle membrane
- neuron projection
- axon
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- kinesin binding
- plus-end-directed microtubule motor activity
- microtubule binding