CNST Gene Summary [Human]
Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]
Details
| Type | Processed Transcript |
| Official Symbol | CNST |
| Official Name | consortin, connexin sorting protein [Source:HGNC Symbol;Acc:HGNC:26486] |
| Ensembl ID | ENSG00000162852 |
| Bio databases IDs | |
| Aliases | consortin, connexin sorting protein, protein phosphatase 1, regulatory subunit 64 |
| Synonyms | 9630058J23Rik, C1orf71, consortin, connexin sorting protein, LOC100134211, LOC100912475, PPP1R64, RGD1564833 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CNST often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Consortin C-terminus
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- trans Golgi network
- transport vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CNST gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Golgi to plasma membrane protein transport
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- intracellular membrane-bounded organelle
- membrane
- macromolecular complex
- transport vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein binding
- connexin binding