CDCA8 Gene Summary [Human]
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
Details
| Type | Protein Coding |
| Official Symbol | CDCA8 |
| Official Name | cell division cycle associated 8 [Source:HGNC Symbol;Acc:HGNC:14629] |
| Ensembl ID | ENSG00000134690 |
| Bio databases IDs | |
| Aliases | cell division cycle associated 8, borealin |
| Synonyms | 4831429J16Rik, BOR, BOREALIN, cell division cycle associated 8, D4ERTD421E, DasraB, MESRGP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDCA8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aurora b phosphorylation site
- Nbl1 / Borealin N terminal
- protein binding
- Cell division cycle-associated protein 8
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- endometrial cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- bladder cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
role in cell
- expression in
- synthesis in
- phosphorylation in
- survival
- growth
- invasion by
- migration
- cell viability
- mitosis
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- contractile rings
- midbody
- cytoplasmic bridges
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- centromeres
- chromosomal arms
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDCA8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle midzone assembly involved in mitosis
- positive regulation of mitotic cell cycle spindle assembly checkpoint
- chromosome organization
- cytokinesis after mitosis
- mitotic sister chromatid segregation
- mitotic metaphase plate congression
- mitotic cell cycle
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- spindle midzone
- intercellular bridge
- microtubule cytoskeleton
- chromocenter
- cytosol
- macromolecular complex
- chromosome passenger complex
- midbody
- nucleolus
- chromosome, centromeric region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding