BORCS8-MEF2B Gene Summary [Human]
This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | BORCS8-MEF2B |
| Official Name | BORCS8-MEF2B readthrough [Source:HGNC Symbol;Acc:HGNC:39979] |
| Ensembl ID | ENSG00000064489 |
| Bio databases IDs | |
| Aliases | BORCS8-MEF2B readthrough |
| Synonyms | 2310045N01RIK, AI451606, BORCS8-MEF2B readthrough, LOC729991, LOC729991-MEF2B, MEF2B, MEF2BNB-MEF2B, RSRFR2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BORCS8-MEF2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MADS
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- SRF-type transcription factor (DNA-binding and dimerization domain)
- nucleic acid binding
- double-stranded DNA binding
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the BORCS8-MEF2B gene in human plays a role, providing insight into its function and relevance in health or disease.
- Apelin Endothelial Signaling Pathway
- Calcium Signaling
- Cardiac Hypertrophy Signaling
- Cellular Effects of Sildenafil (Viagra)
- Cholecystokinin/Gastrin-mediated Signaling
- Corticotropin Releasing Hormone Signaling
- ERK5 Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- p38 MAPK Signaling
- Role of NFAT in Cardiac Hypertrophy
- Role of NFAT in Regulation of the Immune Response
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cell junction
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BORCS8-MEF2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- heart development
- cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cell junction
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity