JUN Gene Summary [Human]
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | JUN |
| Official Name | Jun proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6204] |
| Ensembl ID | ENSG00000177606 |
| Bio databases IDs | |
| Aliases | Jun proto-oncogene, AP-1 transcription factor subunit |
| Synonyms | Activator protein 1, AP-1, API-1, cJUN, Junc, jun proto-oncogene, Jun proto-oncogene, AP-1 transcription factor subunit, LOC100288387, LOC100291417, LOC100293034, p39, v-Jun, V-jun Avian Sarcoma Virus 17 Oncogene Homolog, V-jun Sarcoma Virus 17 Oncogene Homolog |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human JUN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- transcription regulator
- phosphoacceptor site
- transcription activation domain
- transcription factor binding
- GTPase activator
- leucine zipper domain
- chromatin binding
- Jnk-binding domain
- identical protein binding
- bZIP domain
- helicase domain
- docking domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic helix-loop-helix-leucine zipper domain
- ATPase domain
- basic domain
- bZIP
- Jun-like transcription factor
- Jnk phosphorylation site
- proline/glutamine rich region
- ubiquitin protein ligase binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- dimerization domain
- kinase interacting domain
- transcription factor binding domain
- DNA binding domain
- nucleic acid binding
- enzyme binding
- Basic region leucine zipper
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- Delta domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- binding protein
- minimal transactivation domain
- double-stranded DNA binding
- protein homodimerization
- heterodimerization domain
- transcription factor activity
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the JUN gene in human plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- April Mediated Signaling
- Aryl Hydrocarbon Receptor Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- Chemokine Signaling
- CXCR4 Signaling
- ErbB2-ErbB3 Signaling
- GDNF Family Ligand-Receptor Interactions
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- Hypoxia Signaling in the Cardiovascular System
- IGF-1 Signaling
- IL-17A Signaling in Gastric Cells
- IL-2 Signaling
- IL-3 Signaling
- Inhibition of Angiogenesis by TSP1
- PCP pathway
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Th2 Pathway
- Thrombopoietin Signaling
- TNFR1 Signaling
- Toll-like Receptor Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- non-insulin-dependent diabetes mellitus
- rheumatoid arthritis
- celiac disease
- skin squamous cell carcinoma
- squamous cell skin cancer
- actinic keratosis
- endometriosis
- liver cancer
role in cell
- replication in
- production in
- binding
- invasion by
- apoptosis
- phosphorylation in
- molecular cleavage in
- G1 phase
- differentiation
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- cytosol
- chromosome
- nucleoplasm
- clastosomes
- membrane processes
- complex nuclear bodies
- chromatin
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human JUN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation by host of viral transcription
- negative regulation by host of viral transcription
- SMAD protein signal transduction
- transforming growth factor beta receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of DNA binding
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of apoptotic process
- cellular response to cadmium ion
- reactivation of latent virus
- positive regulation of transcription initiation, DNA-dependent
- regulation of cell cycle
- cellular response to reactive oxygen species
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- euchromatin
- AP1 complex
- nuclear chromosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cAMP response element binding
- identical protein binding
- GTPase activator activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- transcription factor binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- small conjugating protein ligase binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA binding
- ubiquitin protein ligase binding
- R-SMAD binding
- enzyme binding