GLP2R Gene Summary [Human]
This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | GLP2R |
| Official Name | glucagon like peptide 2 receptor [Source:HGNC Symbol;Acc:HGNC:4325] |
| Ensembl ID | ENSG00000065325 |
| Bio databases IDs | |
| Aliases | glucagon like peptide 2 receptor |
| Synonyms | 9530092J08Rik, GLP-2, glucagon-like peptide 2 receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GLP2R often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- glucagon receptor
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GLP2R gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- short bowel syndrome
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- hyperlipidemia
- susceptibility to type 2 diabetes mellitus
- Hirschsprung disease
role in cell
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GLP2R gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to glucagon stimulus
- positive regulation of cell proliferation
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- glucagon receptor activity
- peptide hormone binding