Glp2r Gene Summary [Mouse]
Predicted to enable glucagon receptor activity and peptide hormone binding activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in foregut-midgut junction; hindgut; midgut; and rectum. Orthologous to human GLP2R (glucagon like peptide 2 receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Glp2r |
| Official Name | glucagon-like peptide 2 receptor [Source:MGI Symbol;Acc:MGI:2136733] |
| Ensembl ID | ENSMUSG00000049928 |
| Bio databases IDs | |
| Aliases | glucagon-like peptide 2 receptor |
| Synonyms | 9530092J08Rik, GLP-2, glucagon-like peptide 2 receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Glp2r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- glucagon receptor
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Glp2r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- short bowel syndrome
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- hyperlipidemia
- susceptibility to type 2 diabetes mellitus
- Hirschsprung disease
role in cell
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Glp2r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to glucagon stimulus
- positive regulation of cell proliferation
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- glucagon receptor activity
- peptide hormone binding