PACC1 Gene Summary [Human]
Enables pH-gated chloride channel activity. Involved in chloride transport. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PACC1 |
| Official Name | proton activated chloride channel 1 [Source:HGNC Symbol;Acc:HGNC:25593] |
| Ensembl ID | ENSG00000065600 |
| Bio databases IDs | |
| Aliases | proton activated chloride channel 1, acid-sensitive outwardly rectifying channel |
| Synonyms | 2310028N02Rik, ASOR, C1orf75, hPAC, hTMEM206, LOC55248, PAC, PAORAC, proton activated chloride channel 1, RGD1359339, TMEM206 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PACC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- anion channel
- TMEM206 protein family
- chloride channel
- ligand-gated ion channel
- protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PACC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chloride transport
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding