DAB2IP Gene Summary [Human]
DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | DAB2IP |
| Official Name | DAB2 interacting protein [Source:HGNC Symbol;Acc:HGNC:17294] |
| Ensembl ID | ENSG00000136848 |
| Bio databases IDs | |
| Aliases | DAB2 interacting protein, nGAP-like protein, DOC-2/DAB2 interactive protein, ASK-interacting protein, ASK1-interacting protein 1 |
| Synonyms | 2310011D08Rik, AF9Q34, AI480459, AIP-1, DAB2 interacting protein, DIP1/2, disabled 2 interacting protein, LOC108350356, mKIAA1743 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DAB2IP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- death receptor binding
- C2 region of HIV-1 gp120
- protein binding activity, bridging
- GTPase activator
- leucine zipper domain
- GTPase Activating Protein domain
- identical protein binding
- proline rich domain
- Domain of unknown function (DUF3498)
- Ras GTPase Activating Domain
- GTPase-activator protein for Ras-like GTPases
- GTPase-activator protein for Ras-like GTPase
- serine phosphorylation site
- PR domain
- GTPase activating protein binding domain
- C2 domain
- period-like domain
- protein kinase binding
- protein phosphatase binding
- protein binding
- Pleckstrin homology-like domain
- vascular endothelial growth factor receptor binding
- phosphatidylinositol binding
- SH3-domain binding
- phosphorylation site
- protein kinase activator
- phosphoinositide 3-kinase binding
- binding protein
- kinase binding
- protein homodimerization
- Protein kinase C conserved region 2 (CalB)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- neoplasia
- metastasis
- organismal death
- prostate cancer
- advanced cancer
- cancer
- colon adenocarcinoma
- colon epithelial cancer
- coronary artery disease
role in cell
- survival
- expression in
- size
- phosphorylation in
- cell death
- stabilization in
- epithelial-mesenchymal transition
- apoptosis
- proliferation
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- endosomes
- cytosol
- microdomains
- endocytotic vesicle
- perikaryon
- axons
- dendrites
- mossy fiber boutons
- parallel fiber
- climbing fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DAB2IP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- positive regulation of JUN kinase activity
- negative regulation of protein catabolic process
- induction of apoptosis via death domain receptors
- negative regulation of epidermal growth factor receptor signaling pathway
- inflammatory response
- negative regulation of Ras protein signal transduction
- negative regulation of transcription, DNA-dependent
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- cellular response to unfolded protein
- positive regulation of neuron projection development
- regulation of cell cycle
- intracellular signal transduction
- negative regulation of GTPase activity
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of toll-like receptor 4 signaling pathway
- positive regulation of protein catabolic process
- regulation of p38MAPK cascade
- negative regulation of epithelial cell proliferation
- cellular response to epidermal growth factor stimulus
- regulation of GTPase activity
- endothelial cell apoptotic process
- negative regulation of G0 to G1 transition
- tube formation
- negative regulation of protein kinase B signaling cascade
- negative regulation of MAP kinase activity
- layer formation in cerebral cortex
- negative regulation of cell proliferation
- cell motility involved in cerebral cortex radial glia guided migration
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- neuron projection morphogenesis
- regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of vascular endothelial growth factor signaling pathway
- negative regulation of epithelial to mesenchymal transition
- angiogenesis
- negative regulation of fibroblast proliferation
- negative regulation of epithelial cell migration
- cellular response to tumor necrosis factor
- negative regulation of endothelial cell migration
- positive regulation of protein complex assembly
- positive regulation of neuron migration
- positive regulation of synapse maturation
- protein catabolic process
- regulation of protein complex assembly
- positive regulation of MAPK cascade
- positive regulation of dendrite development
- negative regulation of canonical Wnt receptor signaling pathway
- cellular response to lipopolysaccharide
- negative regulation of ERK1 and ERK2 cascade
- innate immune response
- positive regulation of JNK cascade
- positive regulation of apoptotic process
- cellular response to interleukin-1
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- cellular response to vascular endothelial growth factor stimulus
- negative regulation of protein serine/threonine kinase activity
- positive regulation of protein serine/threonine kinase activity
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- dendrite
- cytoplasm
- cerebellar mossy fiber
- cytosol
- neuronal cell body membrane
- neuronal cell body
- climbing fiber
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase binding
- protein kinase binding
- Toll-like receptor 4 binding
- identical protein binding
- protein serine/threonine kinase activator activity
- protein homodimerization activity
- signaling adaptor activity
- GTPase activator activity
- death receptor binding
- phosphatidylinositol-4-phosphate binding
- protein binding
- vascular endothelial growth factor receptor 2 binding
- cadherin binding
- phosphatidylinositol-3-phosphate binding
- SH3 domain binding
- mitogen-activated protein kinase kinase kinase binding
- protein phosphatase 2A binding
- kinase binding
- 14-3-3 protein binding
- mitogen-activated protein kinase kinase binding