CLEC2D Gene Summary [Human]
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CLEC2D |
| Official Name | C-type lectin domain family 2 member D [Source:HGNC Symbol;Acc:HGNC:14351] |
| Ensembl ID | ENSG00000069493 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 2 member D, C-type lectin related f, lectin-like transcript 1 |
| Synonyms | CLAX, C-type lectin domain family 2 member D, LLT1, OCIL |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLEC2D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- ectodomain
- Lectin C-type domain
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- glioblastoma
- glioblastoma cancer
- autoimmune thyroid disease
- glioma
- glioma formation
- insulin-dependent diabetes mellitus
role in cell
- inhibition
- downregulation in
- activation
- function
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLEC2D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- carbohydrate binding