SEMA4F Gene Summary [Human]
This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | SEMA4F |
| Official Name | ssemaphorin 4F [Source:HGNC Symbol;Acc:HGNC:10734] |
| Ensembl ID | ENSG00000135622 |
| Bio databases IDs | |
| Aliases | ssemaphorin 4F, m-Sema M |
| Synonyms | LOC105374808, M-SEMA, m-Sema-M, PRO2353, S4F, sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain, SEMAM, SEMAW, ssemaphorin 4F |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEMA4F often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- Plexin repeat
- immunoglobulin domain
- Semaphorin 4F C-terminal
- protein binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the SEMA4F gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- Endoplasmic Reticulum
- postsynaptic membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEMA4F gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- retinal ganglion cell axon guidance
- neural crest cell migration
- negative regulation of axon extension
- nervous system development
- cell-cell signaling
- axon guidance
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- membrane
- endoplasmic reticulum
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chemorepellent activity
- semaphorin receptor binding