S1PR1 Gene Summary [Human]
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | S1PR1 |
| Official Name | sphingosine-1-phosphate receptor 1 [Source:HGNC Symbol;Acc:HGNC:3165] |
| Ensembl ID | ENSG00000170989 |
| Bio databases IDs | |
| Aliases | sphingosine-1-phosphate receptor 1 |
| Synonyms | CD363, CHEDG1, D1S3362, ECGF1, EDG-1, Endothelial differentiation sphingolipid g-protein-coupled receptor 1, Lpb1, S1p, S1P1, SPHINGOSINE-1-P GPCR, sphingosine-1-phosphate receptor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human S1PR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- bioactive lipid receptor
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- sphingolipid binding
- serine-rich region
- G-protein-coupled receptor binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- glycosylation site
Pathways
Biological processes and signaling networks where the S1PR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- cAMP-mediated signaling
- Cellular Effects of Sildenafil (Viagra)
- Ceramide Signaling
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Gαi Signaling
- Phagosome Formation
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Sphingosine-1-phosphate Signaling
- Th1 and Th2 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- ulcerative colitis
- chronic lymphocytic leukemia
- lung squamous cell carcinoma
- squamous cell lung cancer
- spinal cord demyelination
- mixed papillary and follicular thyroid cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
role in cell
- migration
- expression in
- phosphorylation in
- production in
- formation
- survival
- apoptosis
- activation in
- proliferation
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- caveolae fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- presynaptic regions
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- vesicles
- cell-cell contacts
- plasma membrane extracellular face
- caveolae
- nucleoplasm
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human S1PR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- endothelial cell differentiation
- cell adhesion
- regulation of bone resorption
- positive regulation of transcription from RNA polymerase II promoter
- sphingosine-1-phosphate signaling pathway
- positive regulation of smooth muscle cell proliferation
- chemotaxis
- angiogenesis
- regulation of metabolic process
- cell migration
- transmission of nerve impulse
- regulation of bone mineralization
- G-protein coupled receptor signaling pathway
- neuron differentiation
- heart trabecula morphogenesis
- positive regulation of positive chemotaxis
- brain development
- phospholipase C-activating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cardiac muscle tissue growth involved in heart morphogenesis
- negative regulation of stress fiber assembly
- blood vessel maturation
- T cell migration
- lamellipodium assembly
- regulation of cell adhesion
- leukocyte chemotaxis
- actin cytoskeleton organization
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane raft
- external side of plasma membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- sphingosine-1-phosphate receptor activity
- G-protein coupled receptor activity
- protein binding
- sphingolipid binding