RHOBTB3 Gene Summary [Human]
Enables ATP binding activity and small GTPase binding activity. Involved in retrograde transport, endosome to Golgi. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | RHOBTB3 |
| Official Name | Rho related BTB domain containing 3 [Source:HGNC Symbol;Acc:HGNC:18757] |
| Ensembl ID | ENSG00000164292 |
| Bio databases IDs | |
| Aliases | Rho related BTB domain containing 3 |
| Synonyms | 1700040C17Rik, 2610033K01Rik, 4930503C18Rik, KIAA0878, mKIAA0878, Rho-related BTB domain containing 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RHOBTB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- ATP binding
- enzyme binding
- BTB/POZ domain
- enzyme
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- ATPase
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- non-insulin-dependent diabetes mellitus
- opioid dependence
- metastasis
- organismal death
- pancreatic epithelial cancer
- Huntington disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
- neoplasia
role in cell
- expression in
- migration
- proliferation
- binding in
- fragmentation
- invasion by
- degradation in
- autophagy in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RHOBTB3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- male gonad development
- regulation of proteolysis
- retrograde transport, endosome to Golgi
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- ubiquitin protein ligase binding
- GTPase activity
- small GTPase binding