DNAJC10 Gene Summary [Human]
This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | DNAJC10 |
| Official Name | DnaJ heat shock protein family (Hsp40) member C10 [Source:HGNC Symbol;Acc:HGNC:24637] |
| Ensembl ID | ENSG00000077232 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member C10, protein disulfide isomerase family A, member 19 |
| Synonyms | 1200006L06Rik, D2Ertd706e, DnaJ heat shock protein family (Hsp40) member C10, ERdj5, JPDI, MTHr, PDIA19 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNAJC10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- Hsp70 protein binding
- thioredoxin-like domain
- protein disulfide oxidoreductase
- sulfur group:disulfide oxidoreductase
- enzyme
- protein binding
- thioredoxin
- DnaJ domain
- DnaJ
- ATPase binding
- disulfide oxidoreductase
- DnaJ molecular chaperone homology domain
- protein disulfide isomerase, eukaryotic
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- chaperone binding
Pathways
Biological processes and signaling networks where the DNAJC10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DNAJC10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of ATPase activity
- negative regulation of protein phosphorylation
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- response to endoplasmic reticulum stress
- protein folding in endoplasmic reticulum
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- membrane
- endoplasmic reticulum
- endoplasmic reticulum chaperone complex
Molecular Function
What the gene product does at the molecular level
- disulfide oxidoreductase activity
- protein disulfide oxidoreductase activity
- protein binding
- chaperone binding
- oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
- ATPase activator activity
- misfolded protein binding
- ATPase binding
- Hsp70 protein binding