IFI16 Gene Summary [Human]
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
Details
| Type | Protein Coding |
| Official Symbol | IFI16 |
| Official Name | interferon gamma inducible protein 16 [Source:HGNC Symbol;Acc:HGNC:5395] |
| Ensembl ID | ENSG00000163565 |
| Bio databases IDs | |
| Aliases | interferon gamma inducible protein 16 |
| Synonyms | IFI16B, IFI204, IFNGIP1, interferon gamma inducible protein 16, interferon γ inducible protein 16, PYHIN2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFI16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- PAAD/DAPIN/Pyrin domain
- nuclear export signal
- HINa DNA-binding domain
- nuclear localization sequence
- linker domain
- transcription factor binding
- protein binding
- HIN-200/IF120x domain
- identical protein binding
- arginine-lysine rich domain
- HINb DNA-binding domain
- double-stranded DNA binding
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian carcinoma
- psoriasis
- gout
- atopic dermatitis
- immunological disorder
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- epithelial ovarian cancer
- Sjögren syndrome
role in cell
- apoptosis
- expression in
- growth
- recruitment in
- binding in
- proliferation
- differentiation
- activation in
- migration
- cytostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFI16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of innate immune response
- negative regulation of transcription from RNA polymerase II promoter
- inflammatory response
- negative regulation of DNA binding
- negative regulation of transcription, DNA-dependent
- activation of innate immune response
- activation of cysteine-type endopeptidase activity
- autophagy
- cellular response to ionizing radiation
- defense response to virus
- monocyte differentiation
- negative regulation of cysteine-type endopeptidase activity
- negative regulation of viral genome replication
- cellular response to interferon-beta
- negative regulation of gene expression, epigenetic
- cellular response to glucose starvation
- innate immune response
- signal transduction by p53 class mediator resulting in induction of apoptosis
- regulation of autophagy
- myeloid cell differentiation
- positive regulation of cytokine production
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- membrane
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- double-stranded DNA binding
- transcription factor binding