CNOT4 Gene Summary [Human]
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | CNOT4 |
| Official Name | CCR4-NOT transcription complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:7880] |
| Ensembl ID | ENSG00000080802 |
| Bio databases IDs | |
| Aliases | CCR4-NOT transcription complex subunit 4 |
| Synonyms | Ccr4-not4, CCR4-NOT transcription complex subunit 4, CCR4-NOT transcription complex, subunit 4, CLONE243, NOT4, NOT4H, Not4hp |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CNOT4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- RING/Ubox like zinc-binding domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- BRcat_Rcat_RBR
- enzyme
- Ring finger domain
- protein binding
- Double zinc ribbon domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- opioid-related disorder
- cannabis dependence
- peripheral arterial disease
role in cell
- differentiation
- TAK-901 resistance
- signaling in
- tanespimycin resistance
- pravastatin sensitivity
- thenoyltrifluoroacetone sensitivity
- dichloroacetic acid sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CNOT4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of megakaryocyte differentiation
- nuclear-transcribed mRNA poly(A) tail shortening
- protein autoubiquitination
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- CCR4-NOT complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- RNA binding
- protein binding
- metal ion binding