RARA Gene Summary [Human]
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | RARA |
| Official Name | retinoic acid receptor alpha [Source:HGNC Symbol;Acc:HGNC:9864] |
| Ensembl ID | ENSG00000131759 |
| Bio databases IDs | |
| Aliases | retinoic acid receptor alpha |
| Synonyms | alpha RAR, NR1B1, RAR, RAR-alpha, RARalpha1, RAR-α, RARα1, retinoic acid receptor alpha, retinoic acid receptor, alpha, Retinoic acid receptor α, retinoic acid receptor, α, α RAR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RARA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger DNA binding domain
- silencing domain
- A/B region
- transcription factor binding
- fxfp sequence
- hormone binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- nuclear receptor ligand binding domain
- ligand-dependent nuclear receptor
- Pka phosphorylation site
- activation domain
- protein kinase binding
- DNA binding domain
- amphipathic helix
- nucleic acid binding
- actinin binding
- protein binding
- sequence-specific DNA binding
- L box domain
- mRNA 5' UTR binding
- hinge domain
- heterodimerization domain
- transcription factor activity
- transcription regulator
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- transcription activation domain
- chromatin binding
- AF-2 transcription activation domain
- retinoid binding
- TA box
- CoR box
- Hdac1 binding domain
- H helix
- AF-1 domain
- ligand-binding domain
- A domain
- protein kinase A binding
- dimerization domain
- camkii phosphorylation site
- Proline-directed phosphorylation site
- alpha helix
- enzyme binding
- protein domain specific binding
- histone deacetylase binding
- receptor binding
- DNA binding
- phosphorylation site
- binding protein
- double-stranded DNA binding
- nucleic acid binding translation repressor
- Ligand-binding domain of nuclear hormone receptor
Pathways
Biological processes and signaling networks where the RARA gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Aryl Hydrocarbon Receptor Signaling
- FXR/RXR Activation
- Glucocorticoid Receptor Signaling
- Hepatic Cholestasis
- LPS/IL-1 Mediated Inhibition of RXR Function
- RAR Activation
- Retinoic acid Mediated Apoptosis Signaling
- Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- neoplasia
- psoriasis
- acne vulgaris
- dilation of ureter
- type M3 acute myeloid leukemia
- plaque psoriasis
- lymphomagenesis
- cancer
- hematologic cancer
role in cell
- expression in
- differentiation
- cellular infiltration by
- activation in
- proliferation
- apoptosis
- transcription in
- cell viability
- quantity
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- GW body
- Cytoplasm
- perinuclear region
- actin cytoskeleton
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
- chromatin
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RARA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular cardiac muscle cell differentiation
- face development
- hormone-mediated signaling pathway
- response to retinoic acid
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of synaptic plasticity
- negative regulation of interferon-gamma production
- negative regulation of translation
- negative regulation of tumor necrosis factor production
- mRNA transcription from RNA polymerase II promoter
- chondroblast differentiation
- embryonic camera-type eye development
- apoptotic cell clearance
- regulation of apoptotic process
- positive regulation of binding
- growth plate cartilage development
- response to estradiol stimulus
- prostate gland development
- negative regulation of granulocyte differentiation
- positive regulation of interleukin-4 production
- positive regulation of interleukin-5 production
- multicellular organism growth
- response to cytokine stimulus
- negative regulation of cartilage development
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- positive regulation of cell cycle
- positive regulation of neuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- glandular epithelial cell development
- negative regulation of transcription from RNA polymerase II promoter
- response to ethanol
- retinoic acid receptor signaling pathway
- neural tube closure
- liver development
- germ cell development
- limb development
- Sertoli cell fate commitment
- female pregnancy
- hippocampus development
- positive regulation of T-helper 2 cell differentiation
- cellular response to estrogen stimulus
- trachea cartilage development
- positive regulation of interleukin-13 production
- cellular response to lipopolysaccharide
- cellular response to retinoic acid
- ureteric bud development
- cell differentiation
- regulation of myelination
- response to vitamin A
Cellular Component
Where in the cell the gene product is active
- nucleolus
- chromatin
- plasma membrane
- nucleoplasm
- dendrite
- nucleus
- transcription factor complex
- perinuclear region of cytoplasm
- cytoplasm
- actin cytoskeleton
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- zinc ion binding
- protein domain specific binding
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- translation repressor activity, nucleic acid binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- alpha-actinin binding
- protein kinase B binding
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
- chromatin binding
- retinoic acid-responsive element binding
- receptor binding
- transcription coactivator binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- retinoic acid binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- mRNA 5'-UTR binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- protein kinase A binding
- enzyme binding