Cnot4 Gene Summary [Mouse]
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein autoubiquitination; regulation of megakaryocyte differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of CCR4-NOT complex. Is expressed in several structures, including central nervous system; genitourinary system; neural retina; and olfactory epithelium. Orthologous to human CNOT4 (CCR4-NOT transcription complex subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cnot4 |
| Official Name | CCR4-NOT transcription complex, subunit 4 [Source:MGI Symbol;Acc:MGI:1859026] |
| Ensembl ID | ENSMUSG00000038784 |
| Bio databases IDs | |
| Aliases | CCR4-NOT transcription complex, subunit 4 |
| Synonyms | Ccr4-not4, CCR4-NOT transcription complex subunit 4, CCR4-NOT transcription complex, subunit 4, CLONE243, NOT4, NOT4H, Not4hp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnot4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- RING/Ubox like zinc-binding domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- BRcat_Rcat_RBR
- enzyme
- Ring finger domain
- protein binding
- Double zinc ribbon domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- opioid-related disorder
- cannabis dependence
- peripheral arterial disease
role in cell
- differentiation
- TAK-901 resistance
- signaling in
- tanespimycin resistance
- pravastatin sensitivity
- thenoyltrifluoroacetone sensitivity
- dichloroacetic acid sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnot4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of megakaryocyte differentiation
- nuclear-transcribed mRNA poly(A) tail shortening
- protein autoubiquitination
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- CCR4-NOT complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- RNA binding
- protein binding
- metal ion binding