STK17B Gene Summary [Human]
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction; positive regulation of fibroblast apoptotic process; and protein phosphorylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | STK17B |
| Official Name | serine/threonine kinase 17b [Source:HGNC Symbol;Acc:HGNC:11396] |
| Ensembl ID | ENSG00000081320 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 17b, death-associated protein kinase-related 2 |
| Synonyms | 3110009A03Rik, DRAK2, serine/threonine kinase 17b, serine/threonine kinase 17b (apoptosis-inducing) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK17B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- Waldenström macroglobulinemia
- systemic lupus erythematosus
- non-Hodgkin lymphoma
role in cell
- proliferation
- apoptosis
- quantity
- number
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- actin cytoskeleton
- Mitochondria
- Flemming body
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK17B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of apoptotic process
- apoptotic process
- positive regulation of fibroblast apoptotic process
- protein autophosphorylation
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- actin cytoskeleton
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase activity
- protein serine/threonine kinase activity