PRKD2 Gene Summary [Human]
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PRKD2 |
| Official Name | protein kinase D2 [Source:HGNC Symbol;Acc:HGNC:17293] |
| Ensembl ID | ENSG00000105287 |
| Bio databases IDs | |
| Aliases | protein kinase D2 |
| Synonyms | AI325941, HSPC187, nPKC-D2, PKD2, Protein kinase d2, RGD1308054 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- protein kinase C binding
- C1A domain
- protein binding
- Pleckstrin homology-like domain
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- C1B domain
- protein kinase C
- PDZ binding motif
Pathways
Biological processes and signaling networks where the PRKD2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- primary sclerosing cholangitis
- chronic lymphocytic leukemia
- coronary artery disease
- neoplasia
- lymphoma
- lymphomagenesis
- abdominal aortic aneurysm
- colorectal cancer
role in cell
- expression in
- degradation in
- proliferation
- survival
- apoptosis
- phosphorylation in
- activation in
- binding in
- cell death
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- invadopodia
- perinuclear region
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- nucleoplasm
- transverse tubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endothelial tube morphogenesis
- protein autophosphorylation
- positive regulation of fibroblast growth factor receptor signaling pathway
- cell adhesion
- positive regulation of cell adhesion
- positive regulation of sequence-specific DNA binding transcription factor activity
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of angiogenesis
- angiogenesis
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- positive regulation of endothelial cell chemotaxis
- positive regulation of DNA biosynthetic process
- positive regulation of endothelial cell migration
- intracellular signal transduction
- T cell receptor signaling pathway
- sphingolipid biosynthetic process
- positive regulation of interleukin-2 production
- adaptive immune response
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of blood vessel endothelial cell migration
- positive regulation of T cell receptor signaling pathway
- vascular endothelial growth factor receptor signaling pathway
- positive regulation of interleukin-8 production
- regulation of T cell apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- cellular response to vascular endothelial growth factor stimulus
- positive regulation of endothelial cell proliferation
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- ATP binding
- protein binding
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity
- protein kinase C activity