KCNK2 Gene Summary [Human]
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | KCNK2 |
| Official Name | potassium two pore domain channel subfamily K member 2 [Source:HGNC Symbol;Acc:HGNC:6277] |
| Ensembl ID | ENSG00000082482 |
| Bio databases IDs | |
| Aliases | potassium two pore domain channel subfamily K member 2 |
| Synonyms | A430027H14Rik, hTREK-1c, hTREK-1e, K2P2.1, potassium channel, subfamily K, member 2, potassium two pore domain channel subfamily K member 2, rTREK1d, TPKC1, TREK, TREK-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCNK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- outward rectifier potassium channel
- channel/pore class transporter
- protein binding
- pore domain
- identical protein binding
- potassium channel inhibitor
- ion channel
- voltage-gated potassium channel
- transmembrane domain
- extracellular loop
- mechanically-gated ion channel
- protein heterodimerization
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- seizures
- prostate cancer
- major depression
- experimental autoimmune encephalomyelitis
- Huntington disease
- prostatic intraepithelial neoplasia
- prostatic adenocarcinoma
- prostatic carcinoma
- cleft lip
role in cell
- proliferation
- expression in
- opening
- opening in
- cellular infiltration by
- transmembrane potential
- excitation
- transmigration
- response by
- action potential in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- apical membrane
- synaptic membrane
- nodes of Ranvier
- synapse
- perikaryon
- axons
- dendrites
- axon terminals
- astrocyte projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KCNK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cardiac muscle cell proliferation
- potassium ion transmembrane transport
- cochlea development
- G-protein coupled receptor signaling pathway
- response to axon injury
- cardiac ventricle development
- memory
- positive regulation of cellular response to hypoxia
- response to mechanical stimulus
- cellular response to hypoxia
- stabilization of membrane potential
- negative regulation of DNA biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- voltage-gated potassium channel complex
- neuronal cell body
- apical plasma membrane
- plasma membrane
- calyx of Held
- cell surface
Molecular Function
What the gene product does at the molecular level
- outward rectifier potassium channel activity
- potassium ion leak channel activity