Kcnk2 Gene Summary [Mouse]
Enables channel activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including chloride transmembrane transport; glutamate secretion; and neuronal action potential. Acts upstream of or within G protein-coupled receptor signaling pathway; potassium ion transport; and regulation of membrane potential. Located in astrocyte projection; dendrite; and plasma membrane. Part of voltage-gated potassium channel complex. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including brain; early conceptus; limb; olfactory epithelium; and secondary oocyte. Orthologous to human KCNK2 (potassium two pore domain channel subfamily K member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnk2 |
| Official Name | potassium channel, subfamily K, member 2 [Source:MGI Symbol;Acc:MGI:109366] |
| Ensembl ID | ENSMUSG00000037624 |
| Bio databases IDs | |
| Aliases | potassium channel, subfamily K, member 2 |
| Synonyms | A430027H14Rik, hTREK-1c, hTREK-1e, K2P2.1, potassium channel, subfamily K, member 2, potassium two pore domain channel subfamily K member 2, rTREK1d, TPKC1, TREK, TREK-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- outward rectifier potassium channel
- channel/pore class transporter
- protein binding
- pore domain
- identical protein binding
- potassium channel inhibitor
- ion channel
- voltage-gated potassium channel
- transmembrane domain
- extracellular loop
- mechanically-gated ion channel
- protein heterodimerization
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- seizures
- prostate cancer
- major depression
- experimental autoimmune encephalomyelitis
- Huntington disease
- prostatic intraepithelial neoplasia
- prostatic adenocarcinoma
- prostatic carcinoma
- cleft lip
regulated by
- HTT
- arachidonic acid
- chloropromazine
- ethyl ether
- tetradecanoylphorbol acetate
- H+
- adenosine triphosphate
- cyclic AMP
- dexamethasone
- Gstp1 (includes others)
role in cell
- proliferation
- expression in
- opening
- opening in
- cellular infiltration by
- transmembrane potential
- excitation
- transmigration
- response by
- action potential in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- apical membrane
- synaptic membrane
- nodes of Ranvier
- synapse
- perikaryon
- axons
- dendrites
- axon terminals
- astrocyte projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cardiac muscle cell proliferation
- potassium ion transmembrane transport
- cochlea development
- G-protein coupled receptor signaling pathway
- response to axon injury
- cardiac ventricle development
- memory
- positive regulation of cellular response to hypoxia
- response to mechanical stimulus
- cellular response to hypoxia
- stabilization of membrane potential
- negative regulation of DNA biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- voltage-gated potassium channel complex
- neuronal cell body
- apical plasma membrane
- plasma membrane
- calyx of Held
- cell surface
Molecular Function
What the gene product does at the molecular level
- outward rectifier potassium channel activity
- potassium ion leak channel activity