RRAGC Gene Summary [Human]
This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | RRAGC |
| Official Name | Ras related GTP binding C [Source:HGNC Symbol;Acc:HGNC:19902] |
| Ensembl ID | ENSG00000116954 |
| Bio databases IDs | |
| Aliases | Ras related GTP binding C |
| Synonyms | GTR2, LNGODS, LNGOS, RAGC, Ras-related GTP binding C, Rragc predicted, TIB929, YGR163W |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RRAGC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Gtr1/RagA G protein conserved region
- protein binding activity, bridging
- GTPase
- enzyme binding
- coiled-coil domain
- leucine zipper domain
- enzyme
- protein binding
- nucleotide-binding domain
- GTP binding
- GDP binding
- protein heterodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- follicular B-cell or T-cell lymphoma
- non-Hodgkin disease
- Long-Olsen-Distelmaier syndrome
role in cell
- phosphorylation in
- binding in
- activation in
- differentiation
- response by
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- lysosome
- cytosol
- lysosome membrane
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RRAGC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- small GTPase mediated signal transduction
- transcription, DNA-dependent
- cellular response to amino acid starvation
- protein localization
- response to amino acid stimulus
- cellular response to starvation
- cellular response to amino acid stimulus
- cellular response to nutrient levels
- negative regulation of autophagy
- apoptotic process
- protein localization in membrane
- regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- lysosomal membrane
- nucleoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- GTP binding
- magnesium ion binding
- protein binding
- protein heterodimerization activity
- protein anchor
- GTPase binding
- GTPase activity
- GDP binding
- binding, bridging