TGOLN2 Gene Summary [Human]

This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Details

Type
Protein Coding
Official Symbol
TGOLN2
Official Name
trans-golgi network protein 2 [Source:HGNC Symbol;Acc:HGNC:15450]
Ensembl ID
ENSG00000152291
Bio databases IDs NCBI: 10618 Ensembl: ENSG00000152291
Aliases trans-golgi network protein 2, trans-Golgi network protein (46, 48, 51kD isoforms)
Synonyms Gmpt1, hTGN46, hTGN48, hTGN51, TGN38, TGN38B, TGN41, TGN46, TGN51, Tgoln1, trans-golgi network protein 2, Ttgn1, TTGN2
Species
Human, Homo sapiens
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TGOLN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • internalization targeting signal
  • endocytic signal motif
  • Keratinocyte-associated gene product
  • cytoplasmic domain
  • protein binding
  • cytosolic tail domain
  • sorting signal domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • peripheral arterial disease
regulated by
role in cell
  • formation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • soluble fraction
  • glutaminergic synapse
  • endocytic vesicle membrane
  • cell surface
  • perinuclear region
  • cellular membrane
  • Golgi apparatus component
  • Plasma Membrane
  • endosomes
  • vesicles
  • Golgi Apparatus
  • endoplasmic reticulum lumen
  • Golgi membrane
  • trans face of the Golgi apparatus
  • trans Golgi network
  • nucleoplasm
  • perinuclear space
  • spine apparatus
  • myofibrils
  • transport vesicles
  • Golgi cisternae
  • perikaryon
  • dendrites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TGOLN2 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum lumen
  • trans-Golgi network
  • clathrin-coated endocytic vesicle membrane
  • endosome
  • trans-Golgi network transport vesicle
  • Golgi apparatus
  • transport vesicle
  • plasma membrane
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.