ZNF446 Gene Summary [Human]
Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNF446 |
| Official Name | zinc finger protein 446 [Source:HGNC Symbol;Acc:HGNC:21036] |
| Ensembl ID | ENSG00000083838 |
| Bio databases IDs | |
| Aliases | zinc finger protein 446 |
| Synonyms | A630035I11Rik, A930031C22, AABR07002065.2, FLJ20626, Zfp446, zinc finger protein 446, ZKSCAN20, ZSCAN30, ZSCAN52 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF446 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- leucine rich region
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- transcription regulator
- SCAN domain
- protein binding
- KRAB (Kruppel-associated box) domain -A box
- identical protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF446 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity