LZTS2 Gene Summary [Human]
The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | LZTS2 |
| Official Name | leucine zipper tumor suppressor 2 [Source:HGNC Symbol;Acc:HGNC:29381] |
| Ensembl ID | ENSG00000107816 |
| Bio databases IDs | |
| Aliases | leucine zipper tumor suppressor 2 |
| Synonyms | LAPSER1, leucine zipper, putative tumor suppressor 2, leucine zipper, putative tumour suppressor 2, leucine zipper tumor suppressor 2, leucine zipper tumour suppressor 2, mKIAA1813 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LZTS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- Fez1
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gallbladder cancer
- biliary tract cancer
- cancer
- neoplasia
- major depression
- dilation of ureter
- hydronephrosis
- pancreatic neoplasia
- epithelial neoplasia
- hematologic cancer
role in cell
- apoptosis
- proliferation
- cell death
- growth
- formation
- colony formation
- transformation
- binucleation
- mitotic catastrophe
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic region
- Plasma Membrane
- vesicles
- centrosome
- midbody
- intercellular junctions
- cytosol
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LZTS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fibroblast proliferation
- negative regulation of canonical Wnt receptor signaling pathway
- primary ureteric bud growth
- ureter morphogenesis
- negative regulation of protein localization to nucleus
- spindle midzone assembly
- microtubule severing
- nuclear export
- negative regulation of fibroblast proliferation
- cytokinesis after mitosis
- Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- centrosome
- vesicle
- cytosol
- midbody
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding