GCKR Gene Summary [Human]
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GCKR |
| Official Name | glucokinase regulator [Source:HGNC Symbol;Acc:HGNC:4196] |
| Ensembl ID | ENSG00000084734 |
| Bio databases IDs | |
| Aliases | glucokinase regulator, hexokinase 4 regulator |
| Synonyms | FGQTL5, GKRP, GLRE, glucokinase regulator, glucokinase regulatory protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GCKR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SIS
- kinase binding
- binding protein
- catalytic domain
- kinase inhibitor activity
- enzyme inhibitor activity
- enzyme binding
- protein domain specific binding
- protein binding
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cholecystitis
- lipoprotein lipase deficiency
- metabolic syndrome X
- nonalcoholic fatty liver disease
- refractive error
- inflammatory bowel disease
- insulin resistance
- gout
- alcoholism
- hyperlipidemia
role in cell
- expression in
- homeostasis in
- sequestration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GCKR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to glucose stimulus
- response to fructose stimulus
- negative regulation of glucokinase activity
- protein import into nucleus
- glucose homeostasis
- triglyceride homeostasis
- urate metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- fructose-6-phosphate binding
- protein binding
- enzyme inhibitor activity
- kinase inhibitor activity
- carbohydrate binding
- enzyme binding