Gckr Gene Summary [Rat]
Enables several functions, including glucose sensor activity; kinase binding activity; and kinase inhibitor activity. Involved in negative regulation of hexokinase activity; protein import into nucleus; and response to hexose. Located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in end stage renal disease and type 2 diabetes mellitus. Orthologous to human GCKR (glucokinase regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gckr |
| Official Name | glucokinase regulator [Source:RGD Symbol;Acc:2671] |
| Ensembl ID | ENSRNOG00000048874 |
| Bio databases IDs | |
| Aliases | glucokinase regulator |
| Synonyms | FGQTL5, GKRP, GLRE, glucokinase regulator, glucokinase regulatory protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gckr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SIS
- kinase binding
- binding protein
- catalytic domain
- kinase inhibitor activity
- enzyme inhibitor activity
- enzyme binding
- protein domain specific binding
- protein binding
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cholecystitis
- lipoprotein lipase deficiency
- metabolic syndrome X
- nonalcoholic fatty liver disease
- refractive error
- inflammatory bowel disease
- insulin resistance
- gout
- alcoholism
- hyperlipidemia
role in cell
- expression in
- homeostasis in
- sequestration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gckr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to glucose stimulus
- response to fructose stimulus
- negative regulation of glucokinase activity
- protein import into nucleus
- glucose homeostasis
- triglyceride homeostasis
- urate metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- fructose-6-phosphate binding
- protein binding
- enzyme inhibitor activity
- kinase inhibitor activity
- carbohydrate binding
- enzyme binding