CETP Gene Summary [Human]
The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Details
| Type | Protein Coding |
| Official Symbol | CETP |
| Official Name | cholesteryl ester transfer protein [Source:HGNC Symbol;Acc:HGNC:1869] |
| Ensembl ID | ENSG00000087237 |
| Bio databases IDs | |
| Aliases | cholesteryl ester transfer protein, BPI fold containing family F |
| Synonyms | BPIFF, Cholesteryl ester transfer, cholesteryl ester transfer protein, HDLCQ10 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CETP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid binding
- cholesterol binding
- lipid binding
- binding protein
- phospholipid transporter
- enzyme
- triglyceride binding
- BPI
- glycosylation site
Pathways
Biological processes and signaling networks where the CETP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- COVID-19
- hepatocellular carcinoma
- age-related macular degeneration
- endometriosis
- metabolic syndrome X
- atherosclerosis
- Alzheimer disease
- exudative age-related macular degeneration
role in cell
- expression in
- accumulation in
- size
- number
- stress response in
- conversion in
- capacitation
- synthesis in
- turnover in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CETP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- very-low-density lipoprotein particle remodeling
- positive regulation of phospholipid transport
- high-density lipoprotein particle remodeling
- lipid homeostasis
- low-density lipoprotein particle remodeling
- triglyceride transport
- cholesterol metabolic process
- triglyceride metabolic process
- cholesterol homeostasis
- phospholipid homeostasis
- lipid transport
- phosphatidylcholine metabolic process
- reverse cholesterol transport
- regulation of cholesterol efflux
- phospholipid transport
- negative regulation of macrophage derived foam cell differentiation
- positive regulation of cholesterol transport
- triglyceride homeostasis
- cholesterol transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- high-density lipoprotein particle
- vesicle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- triglyceride binding
- phospholipid transporter activity
- cholesterol binding
- lipid binding
- phosphatidylcholine binding