CEBPA Gene Summary [Human]
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
Details
| Type | Protein Coding |
| Official Symbol | CEBPA |
| Official Name | CCAAT enhancer binding protein alpha [Source:HGNC Symbol;Acc:HGNC:1833] |
| Ensembl ID | ENSG00000245848 |
| Bio databases IDs | |
| Aliases | CCAAT enhancer binding protein alpha |
| Synonyms | CBF-A, CCAAT enhancer binding protein alpha, CCAAT/enhancer binding protein alpha, CCAAT enhancer binding protein α, CCAAT/enhancer binding protein α, CEBP, Cebp1a, C/EBP-alpha, Cebp Alpha, C/EBP alpha P30, C/EBP alpha P42, CEBPα, C/EBP-α, C/EBP α P30, C/EBP α P42, C/ERB, DBPCEP, p42, Zinc Finger Homeobox 1b |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEBPA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Sumoylation motif
- transcription activation domain
- transcription factor binding
- leucine zipper domain
- chromatin binding
- identical protein binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic helix-loop-helix-leucine zipper domain
- basic domain
- bZIP
- Gsk3 phosphorylation site
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- dimerization domain
- DNA binding domain
- nucleic acid binding
- CR1 domain
- CR2 domain
- Basic region leucine zipper
- histone deacetylase binding
- CR3 domain
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- cyclin-dependent kinase binding domain
- DNA binding
- binding protein
- kinase binding
- E2F protein-binding domain
- double-stranded DNA binding
- protein homodimerization
- transcription factor activity
- protein heterodimerization
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the CEBPA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- squamous cell cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- adenoma formation
- renal clear cell adenocarcinoma
- renal clear cell cancer
- ulcerative colitis
- leukemia
role in cell
- cell death
- expression in
- growth
- quantity
- apoptosis
- acetylation in
- binding in
- proliferation
- migration
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- nucleoplasm
- nucleoli
- nuclear matrix
- chromatin
- pericentric heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEBPA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- negative regulation of cell proliferation
- negative regulation of cell cycle
- cholesterol metabolic process
- positive regulation of fat cell differentiation
- fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- embryonic placenta development
- white fat cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- brown fat cell differentiation
- negative regulation of transcription, DNA-dependent
- cytokine-mediated signaling pathway
- liver development
- positive regulation of macrophage activation
- energy homeostasis
- interleukin-6-mediated signaling pathway
- cellular response to tumor necrosis factor
- regulation of cell cycle
- lung development
- macrophage differentiation
- generation of precursor metabolites and energy
- transcription, DNA-dependent
- epithelial cell maturation
- lipid homeostasis
- positive regulation of inflammatory response
- regulation of transcription, DNA-dependent
- mitochondrion organization
- regulation of transcription from RNA polymerase II promoter
- cellular response to lithium ion
- Notch signaling pathway
- positive regulation of gene expression
- urea cycle
- glucose homeostasis
- myeloid cell differentiation
- hemopoietic stem cell proliferation
- granulocyte differentiation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- cellular response to organic cyclic compound
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- intracellular membrane-bounded organelle
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- chromatin DNA binding
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein homodimerization activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- kinase binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity