SIGLEC1 Gene Summary [Human]
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection. [provided by RefSeq, Dec 2021]
Details
| Type | Protein Coding |
| Official Symbol | SIGLEC1 |
| Official Name | sialic acid binding Ig like lectin 1 [Source:HGNC Symbol;Acc:HGNC:11127] |
| Ensembl ID | ENSG00000088827 |
| Bio databases IDs | |
| Aliases | sialic acid binding Ig like lectin 1 |
| Synonyms | CD169, LOC103690756, LOC688116, MOMA-1, sialic acid binding Ig like lectin 1, sialic acid binding Ig-like lectin 1, sialoadhesin, Sialoadhesin, SN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIGLEC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- virion binding
- Immunoglobulin C1-set domain
- domain 1
- immunoglobulin domain
- domain III
- Immunoglobulin I-set domain
- protein binding
- T-cell surface glycoprotein CD3 delta chain
- CD19_double_Ig
- Penicillin-Binding Protein C-terminus Family
- Immunoglobulin like
- sialic acid-binding domain
- immunoglobulin-like protein domain
- domain 2
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- COVID-19
- nonobstructive azoospermia
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- ATAD3A-related type I interferonopathy
- childhood-onset systemic lupus erythematosus
- antineutrophil cytoplasmic antibody-associated vasculitis
- experimental autoimmune uveoretinitis
- infection by bacteria
- infection by HIV-1
role in cell
- proliferation
- production in
- activation
- quantity
- number
- phagocytosis by
- degradation in
- priming
- uptake by
- capture in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- early endosomes
- late endosomes
- endocytotic vesicle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIGLEC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- negative regulation of type I interferon production
- inflammatory response
- viral entry into host cell via clathrin-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- early endosome
- membrane
- late endosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- virion binding
- carbohydrate binding