CLEC10A Gene Summary [Human]
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CLEC10A |
| Official Name | C-type lectin domain containing 10A [Source:HGNC Symbol;Acc:HGNC:16916] |
| Ensembl ID | ENSG00000132514 |
| Bio databases IDs | |
| Aliases | C-type lectin domain containing 10A, macrophage lectin 2 (calcium dependent) |
| Synonyms | CD301, CLECSF13, CLECSF14, C-type lectin domain containing 10A, DC-ASGPR, HML, HML2, MGL, MGL1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLEC10A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Hepatic lectin, N-terminal domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- protein binding
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- colorectal cancer
- diabetes mellitus
- androgenic alopecia
- ductal breast carcinoma
- ductal breast cancer
role in cell
- proliferation
- production in
- cell death
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLEC10A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interspecies interaction between organisms
- innate immune response
- adaptive immune response
- endocytosis
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- mannose binding
- fucose binding
- carbohydrate binding