KDM1A Gene Summary [Human]
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Details
| Type | Protein Coding |
| Official Symbol | KDM1A |
| Official Name | lysine demethylase 1A [Source:HGNC Symbol;Acc:HGNC:29079] |
| Ensembl ID | ENSG00000004487 |
| Bio databases IDs | |
| Aliases | lysine demethylase 1A, Lysine-specific histone demethylase 1A |
| Synonyms | 1810043O07Rik, AIMAH3, AOF2, BHC110, CPRF, D4Ertd478e, KDM1, KIAA0601, LSD1, lysine demethylase 1A, lysine (K)-specific demethylase 1A, mKIAA0601, RGD1562975 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KDM1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- transcription co-activator
- transcription co-repressor
- androgen receptor binding
- transcription factor binding
- chromatin binding
- enzyme
- identical protein binding
- paired donor oxygen oxidoreductase
- Flavin containing amine oxidoreductase
- flavin adenine dinucleotide binding
- oxidoreductase
- catalytic domain
- nucleic acid binding
- 2-oxoglutarate:oxygen oxidoreductase
- enzyme binding
- p53 binding
- protein binding
- sequence-specific DNA binding
- RNA binding
- double-stranded DNA binding
- NAD(P)-binding Rossmann-like domain
- SWIRM domain
- demethylase activity
- histone demethylase activity
Pathways
Biological processes and signaling networks where the KDM1A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostate cancer
- metastasis
- X-linked bulbospinal atrophy
- primary myelofibrosis
- hippocampal atrophy
- breast carcinoma
- cleft palate, psychomotor retardation and distinctive facial features
- essential thrombocythemia
- gastric cancer
role in cell
- apoptosis
- expression in
- phosphorylation in
- migration
- activation in
- differentiation
- transactivation in
- transcription in
- cell viability
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- extracellular vesicles
- nucleoplasm
- telomeres
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KDM1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein demethylation
- neuron maturation
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of protein binding
- regulation of androgen receptor signaling pathway
- positive regulation of epithelial to mesenchymal transition
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of DNA binding
- negative regulation of transcription, DNA-dependent
- positive regulation of cell size
- cellular response to UV
- positive regulation of protein ubiquitination
- positive regulation of neural precursor cell proliferation
- positive regulation of neuron projection development
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- response to fungicide
- regulation of protein localization
- muscle cell development
- positive regulation of neuroblast proliferation
- negative regulation of sequence-specific DNA binding transcription factor activity
- cerebral cortex development
- regulation of transcription from RNA polymerase II promoter
- guanine metabolic process
- cellular response to gamma radiation
- positive regulation of stem cell proliferation
- cellular response to cAMP
- regulation of double-strand break repair via homologous recombination
- regulation of methylation-dependent chromatin silencing
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- chromosome, telomeric region
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- demethylase activity
- transcription factor binding
- chromatin binding
- MRF binding
- p53 binding
- protein binding
- androgen receptor binding
- transcription coactivator activity
- oxidoreductase activity
- telomeric DNA binding
- flavin adenine dinucleotide binding
- ligand-dependent nuclear receptor transcription coactivator activity
- histone demethylase activity (H3-K9 specific)
- histone demethylase activity
- histone demethylase activity (H3-K4 specific)
- enzyme binding