NDUFB7 Gene Summary [Human]
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | NDUFB7 |
| Official Name | NADH:ubiquinone oxidoreductase subunit B7 [Source:HGNC Symbol;Acc:HGNC:7702] |
| Ensembl ID | ENSG00000099795 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit B7, NADH-ubiquinone oxidoreductase B18 subunit, complex I B18 subunit |
| Synonyms | 1110002H15Rik, B18, CI-B18, MC1DN39, NADH DEHYDROGENASE (UBIQUINONE) 1 beta SUBCOMPLEX, 7, 18KDA, NADH DEHYDROGENASE (UBIQUINONE) 1 β SUBCOMPLEX, 7, 18KDA, NADH:ubiquinone oxidoreductase subunit B7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NDUFB7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
- NADH2 dehydrogenase
- enzyme
- protein binding
- NADH2 dehydrogenase (ubiquinone)
Pathways
Biological processes and signaling networks where the NDUFB7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- insulin resistance
- nuclear type 39 mitochondrial complex I deficiency
- breast cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- mitochondrial disorder
- renal cell carcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial intermembrane space
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NDUFB7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- respiratory chain complex I
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- NADH dehydrogenase (ubiquinone) activity