NDUFV3 Gene Summary [Human]

The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Processed Transcript
Official Symbol
NDUFV3
Official Name
NADH:ubiquinone oxidoreductase subunit V3 [Source:HGNC Symbol;Acc:HGNC:7719]
Ensembl ID
ENSG00000160194
Bio databases IDs NCBI: 4731 Ensembl: ENSG00000160194
Aliases NADH:ubiquinone oxidoreductase subunit V3, complex I 10kDa subunit
Synonyms 1500032D16RIK, CI-10k, CI-9KD, Mipp65, MITOCHONDRIAL COMPLEX 1-10KDA subunit, NADH:ubiquinone oxidoreductase core subunit V3, NADH:ubiquinone oxidoreductase subunit V3, Ndufv3l
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NDUFV3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
  • enzyme
  • protein binding
  • NADH2 dehydrogenase (ubiquinone)

Pathways

Biological processes and signaling networks where the NDUFV3 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • obesity
  • early onset hypertension
  • chromophobe renal cell carcinoma
  • chromophobe renal cancer
  • adult acute myeloid leukemia
  • Huntington disease
  • insulin resistance
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Mitochondria
  • mitochondrial inner membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human NDUFV3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • transmembrane transport
  • mitochondrial electron transport, NADH to ubiquinone
  • aerobic respiration
  • mitochondrial ATP synthesis coupled electron transport
  • mitochondrial ATP synthesis coupled proton transport

Cellular Component

Where in the cell the gene product is active
  • respiratory chain complex I
  • mitochondrion
  • mitochondrial inner membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA binding
  • NADH dehydrogenase (ubiquinone) activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.