DAO Gene Summary [Human]
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | DAO |
| Official Name | D-amino acid oxidase [Source:HGNC Symbol;Acc:HGNC:2671] |
| Ensembl ID | ENSG00000110887 |
| Bio databases IDs | |
| Aliases | D-amino acid oxidase |
| Synonyms | AI987963, DAAO, D-Amino Acid Oxidase, DAMOX, DAO1, DEAMINOACID OXIDASE, OXDA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DAO often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding
- D-amino-acid oxidase
- FAD dependent oxidoreductase
- enzyme
- protein binding
- identical protein binding
- D-amino-acid dehydrogenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Extracellular Space
- microbody
- cytosol
- mitochondrial outer membrane
- synapse
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DAO gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dopamine biosynthetic process
- D-alanine catabolic process
- D-serine metabolic process
- D-serine catabolic process
- digestion
- D-amino acid catabolic process
- proline catabolic process
- neutrophil mediated killing of gram-negative bacterium
Cellular Component
Where in the cell the gene product is active
- presynaptic active zone
- cytoplasm
- cytosol
- peroxisomal matrix
- mitochondrial outer membrane
- extracellular region
- cell projection
Molecular Function
What the gene product does at the molecular level
- FAD binding
- identical protein binding
- protein binding
- D-amino-acid oxidase activity