SEZ6L Gene Summary [Human]
Predicted to act upstream of or within adult locomotory behavior; nervous system development; and regulation of protein kinase C signaling. Predicted to be located in endoplasmic reticulum and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SEZ6L |
| Official Name | seizure related 6 homolog like [Source:HGNC Symbol;Acc:HGNC:10763] |
| Ensembl ID | ENSG00000100095 |
| Bio databases IDs | |
| Aliases | seizure related 6 homolog like |
| Synonyms | Acig1, AIG1, BSRP-B, mKIAA0927, RGD1563628, seizure related 6 homolog like, SEZ6L1, SEZ6L isoform 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEZ6L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- CUB
- ectodomain
- protein binding
- Sushi repeat (SCR repeat)
- SUSHI repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- diabetic ketoacidosis
- coronary artery disease
- insulin resistance
- preeclampsia
- acute myeloid leukemia
- airway obstruction
role in cell
- maturation
- innervation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- Endoplasmic Reticulum
- postsynaptic membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEZ6L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein kinase C signaling cascade
- synapse maturation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- neuronal cell body