MYADM Gene Summary [Human]
Involved in several processes, including negative regulation of heterotypic cell-cell adhesion; negative regulation of macromolecule metabolic process; and negative regulation of protein kinase C signaling. Located in several cellular components, including cortical actin cytoskeleton; membrane raft; and ruffle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | MYADM |
| Official Name | myeloid associated differentiation marker [Source:HGNC Symbol;Acc:HGNC:7544] |
| Ensembl ID | ENSG00000179820 |
| Bio databases IDs | |
| Aliases | myeloid associated differentiation marker |
| Synonyms | D7Wsu62e, LOC91663, myeloid-associated differentiation marker, SB135 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYADM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
role in cell
- expression in
- proliferation
- activation in
- migration
- permeability
- adhesion
- cell spreading
- condensation
- epithelial barrier function
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- ruffle
- cortical actin cytoskeleton
- cell surface
- cellular membrane
- Plasma Membrane
- vesicles
- intercellular junctions
- microsomal membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYADM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- negative regulation of protein kinase C signaling cascade
- negative regulation of actin filament polymerization
- negative regulation of protein phosphorylation
- negative regulation of heterotypic cell-cell adhesion
- regulation of cell-substrate adhesion
- positive regulation of substrate adhesion-dependent cell spreading
- establishment of endothelial barrier
- membrane raft organization
- cell-cell junction maintenance
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- membrane raft
- ruffle
- plasma membrane
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- protein binding