PRICKLE3 Gene Summary [Human]
LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PRICKLE3 |
| Official Name | prickle planar cell polarity protein 3 [Source:HGNC Symbol;Acc:HGNC:6645] |
| Ensembl ID | ENSG00000012211 |
| Bio databases IDs | |
| Aliases | prickle planar cell polarity protein 3 |
| Synonyms | LMO6, LOAM, LOAS, Pk3, prickle planar cell polarity protein 3, Sfc16 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRICKLE3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- PET domain
- protein binding
- PET (Prickle Espinas Testin)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRICKLE3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell projection organization
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding