MOV10 Gene Summary [Human]
Enables 5'-3' RNA helicase activity and RNA binding activity. Involved in defense response to virus; negative regulation of transposition, RNA-mediated; and posttranscriptional regulation of gene expression. Located in P-body and cytosol. Implicated in hypertension. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | MOV10 |
| Official Name | Mov10 RISC complex RNA helicase [Source:HGNC Symbol;Acc:HGNC:7200] |
| Ensembl ID | ENSG00000155363 |
| Bio databases IDs | |
| Aliases | Mov10 RISC complex RNA helicase, functional spliceosome-associated protein 113 |
| Synonyms | Cappa1, Capza1, fSAP113, gb110, Mov10 RISC complex RNA helicase, Mov10 RNA helicase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MOV10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase domain of coronavirus non-structural protein 13
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- RNA helicase
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- hypertension
- thrombocytopenia
role in cell
- replication in
- production in
- neurite outgrowth in
- binding in
- transcription in
- processing in
- reverse transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- GW body
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- Cytoplasm
- cytosol
- spliceosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MOV10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mRNA catabolic process
- 3'-UTR-mediated mRNA destabilization
- posttranscriptional gene silencing by RNA
- gene silencing by miRNA
- negative regulation of transposition, RNA-mediated
- defense response to virus
- mRNA cleavage involved in gene silencing by miRNA
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasmic stress granule
- P granule
- cytoplasmic mRNA processing body
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- 5'-3' RNA helicase activity