HTR2A Gene Summary [Human]
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | HTR2A |
| Official Name | 5-hydroxytryptamine receptor 2A [Source:HGNC Symbol;Acc:HGNC:5293] |
| Ensembl ID | ENSG00000102468 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 2A |
| Synonyms | 5-HT-2, 5-HT-2A, 5-HT2A receptor, 5-HTR2A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine (serotonin) receptor 2A, E030013E04, HTR2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HTR2A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- serotonin binding
- protein binding
- identical protein binding
- 5-HT2 receptor
- seven-transmembrane G protein-coupled receptor superfamily
- protein tyrosine kinase activator
- binding protein
- N-linked glycosylation site
- serotonin receptor
- 7 transmembrane receptor (rhodopsin family)
- PDZ binding motif
- transmembrane receptor
Pathways
Biological processes and signaling networks where the HTR2A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- encephalopathy
- Huntington disease
- cancer
- COVID-19
- pancreatic cancer
- metastasis
- delirium
- tic disorder
- bipolar disorder
- depressive disorder
role in cell
- expression in
- apoptosis
- activation in
- differentiation
- proliferation
- cell rolling
- morphology
- binding
- excitation
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- caveolae fraction
- membrane fraction
- extrasynaptic compartment
- glutaminergic synapse
- Cytoplasm
- cell surface
- perinuclear membrane
- intracellular membranes
- cellular membrane
- granules
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- neurofilaments
- axon hillock
- neurites
- synapse
- transverse tubules
- perikaryon
- dendrites
- dendritic shafts
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HTR2A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- positive regulation of vasoconstriction
- positive regulation of cell proliferation
- positive regulation of fat cell differentiation
- serotonin receptor signaling pathway
- response to xenobiotic stimulus
- negative regulation of potassium ion transport
- memory
- positive regulation of execution phase of apoptosis
- positive regulation of glycolysis
- positive regulation of neuron apoptotic process
- protein localization to cytoskeleton
- protein kinase B signaling cascade
- phospholipase C-activating serotonin receptor signaling pathway
- behavioral response to cocaine
- sensitization
- positive regulation of heat generation
- negative regulation of synaptic transmission, glutamatergic
- positive regulation of phosphatidylinositol biosynthetic process
- release of sequestered calcium ion into cytosol
- positive regulation of DNA biosynthetic process
- urinary bladder smooth muscle contraction
- positive regulation of peptidyl-tyrosine phosphorylation
- regulation of dopamine secretion
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- glycolysis
- positive regulation of inflammatory response
- synaptic transmission
- cellular calcium ion homeostasis
- elevation of cytosolic calcium ion concentration
- positive regulation of cytokine production involved in immune response
- temperature homeostasis
- positive regulation of ERK1 and ERK2 cascade
- detection of mechanical stimulus involved in sensory perception of pain
- artery smooth muscle contraction
- detection of temperature stimulus involved in sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite
- caveola
- postsynaptic membrane
- dendritic shaft
- cell body fiber
- cytoplasmic vesicle
- neuronal cell body
- neurofilament
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serotonin binding
- Gq/11-coupled serotonin receptor activity
- identical protein binding
- protein binding
- neurotransmitter receptor activity
- 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
- protein tyrosine kinase activator activity
- viral receptor activity
- serotonin receptor activity