ARRB2 Gene Summary [Human]
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ARRB2 |
| Official Name | arrestin beta 2 [Source:HGNC Symbol;Acc:HGNC:712] |
| Ensembl ID | ENSG00000141480 |
| Bio databases IDs | |
| Aliases | arrestin beta 2, arrestin 3 |
| Synonyms | AI326910, ARB2, ARR2, Arr3, Arrestin 2, Arrestin-3, arrestin beta 2, arrestin, beta 2, Arrestin β 2, arrestin, β 2, AW122872, BARR2, BARRES, beta-Arrestin 2, β-Arrestin 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARRB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- clathrin binding domain
- protein kinase binding
- G-protein-coupled receptor binding
- enzyme binding
- protein domain specific binding
- Arrestin (or S-antigen), N-terminal domain
- protein binding
- receptor binding
- identical protein binding
- docking domain
- Arrestin (or S-antigen), C-terminal domain
- binding protein
- Ap-2 binding domain
Pathways
Biological processes and signaling networks where the ARRB2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- COVID-19
- heart failure
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung adenocarcinoma
role in cell
- number
- formation
- formation in
- apoptosis
- survival
- cell death
- internalization by
- expression in
- phosphorylation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endocytic vesicle membrane
- intracellular space
- perinuclear region
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- centrosome
- cytosol
- postsynaptic membrane
- basolateral membrane
- Golgi membrane
- nucleoplasm
- dendritic spines
- cytoplasmic vesicles
- endocytotic vesicle
- pseudopodia
- postsynaptic density
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARRB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- negative regulation of interleukin-1 beta production
- transforming growth factor beta receptor signaling pathway
- dopamine receptor signaling pathway
- transcription from RNA polymerase II promoter
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- cell chemotaxis
- adult walking behavior
- negative regulation of protein ubiquitination
- negative regulation of tumor necrosis factor production
- positive regulation of synaptic transmission, dopaminergic
- regulation of excitatory postsynaptic membrane potential
- negative regulation of NF-kappaB transcription factor activity
- positive regulation of receptor internalization
- negative regulation of toll-like receptor signaling pathway
- G-protein coupled receptor internalization
- negative regulation of natural killer cell mediated cytotoxicity
- positive regulation of cardiac muscle cell differentiation
- negative regulation of interleukin-6 production
- proteasomal ubiquitin-dependent protein catabolic process
- desensitization of G-protein coupled receptor protein signaling pathway
- negative regulation of protein phosphorylation
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- negative regulation of interleukin-12 production
- receptor internalization
- positive regulation of protein kinase B signaling cascade
- protein ubiquitination
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- nucleus
- cytoplasm
- coated pit
- cytosol
- cytoplasmic vesicle
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- D1 dopamine receptor binding
- angiotensin receptor binding
- protein binding
- ubiquitin protein ligase binding
- protein kinase B binding
- receptor binding
- binding, bridging
- enzyme binding