KATNAL1 Gene Summary [Human]
Enables identical protein binding activity and microtubule-severing ATPase activity. Involved in microtubule severing. Located in cytoplasm; microtubule; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KATNAL1 |
| Official Name | katanin catalytic subunit A1 like 1 [Source:HGNC Symbol;Acc:HGNC:28361] |
| Ensembl ID | ENSG00000102781 |
| Bio databases IDs | |
| Aliases | katanin catalytic subunit A1 like 1 |
| Synonyms | katanin catalytic subunit A1 like 1, katanin p60 subunit A-like 1, LOC100910196, MGC2599 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KATNAL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- enzyme
- protein binding
- identical protein binding
- microtubule-severing ATPase
- AAA+ lid domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- spindle apparatus
- centrosome
- Mitochondria
- microtubules
- cytosol
- spindle pole
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KATNAL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule severing
- spermatogenesis
- cytoplasmic microtubule organization
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- centrosome
- katanin complex
- cytoplasm
- spindle
- spindle pole
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- protein binding
- microtubule-severing ATPase activity
- microtubule binding
- isomerase activity