LGR6 Gene Summary [Human]
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LGR6 |
| Official Name | leucine rich repeat containing G protein-coupled receptor 6 [Source:HGNC Symbol;Acc:HGNC:19719] |
| Ensembl ID | ENSG00000133067 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing G protein-coupled receptor 6 |
| Synonyms | A530037C04RIK, D830026M09, GPCR, leucine-rich repeat-containing G protein-coupled receptor 6, RGD1560339, VTS20631 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LGR6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- Leucine rich repeat N-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- benign neoplasia
- breast carcinoma
- melanoma
- melanoma cancer
- gastric cancer
- restless legs syndrome
- colon carcinoma
- colon epithelial cancer
- estrogen receptor-negative breast cancer
role in cell
- signaling in
- migration
- proliferation
- tumorigenicity
- colony formation by
- self-renewal capacity
- downregulation in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- vesicles
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LGR6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- negative chemotaxis
- G-protein coupled receptor signaling pathway
- positive regulation of canonical Wnt receptor signaling pathway
- axon guidance
- Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- vesicle
- plasma membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- Roundabout binding
- transmembrane signaling receptor activity
- protein binding
- heparin binding
- protein-hormone receptor activity