Katnal1 Gene Summary [Mouse]
Enables microtubule severing ATPase activity. Acts upstream of or within microtubule severing and spermatogenesis. Located in microtubule cytoskeleton. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human KATNAL1 (katanin catalytic subunit A1 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Katnal1 |
| Official Name | katanin p60 subunit A-like 1 [Source:MGI Symbol;Acc:MGI:2387638] |
| Ensembl ID | ENSMUSG00000041298 |
| Bio databases IDs | |
| Aliases | katanin p60 subunit A-like 1 |
| Synonyms | katanin catalytic subunit A1 like 1, katanin p60 subunit A-like 1, LOC100910196, MGC2599 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Katnal1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- enzyme
- protein binding
- identical protein binding
- microtubule-severing ATPase
- AAA+ lid domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- spindle apparatus
- centrosome
- Mitochondria
- microtubules
- cytosol
- spindle pole
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Katnal1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule severing
- spermatogenesis
- cytoplasmic microtubule organization
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- centrosome
- katanin complex
- cytoplasm
- spindle
- spindle pole
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- protein binding
- microtubule-severing ATPase activity
- microtubule binding
- isomerase activity